Preheat your oven to 400°F (200°C) and line a baking sheet with parchment paper.
In a large mixing bowl, whisk together the flour, granulated sugar, baking powder, and salt.
Add the cold, cubed butter into the dry ingredients. Use a pastry cutter or your fingers to work the butter into the flour until the mixture resembles coarse crumbs.
Gently fold in the chopped cranberries and orange zest.
In a separate bowl, whisk together the buttermilk, egg, and vanilla extract until well combined.
Gradually add the wet ingredients to the dry mixture, mixing until just combined. Be careful not to overwork the dough.
Turn the dough out onto a floured surface and gently knead it a few times until it comes together.
Pat the dough into a circle about 1-inch thick. Cut the dough into wedges (like a pizza) and place them on the prepared baking sheet, leaving space between each scone.
Bake for 15-18 minutes or until the scones are golden brown.
While the scones are baking, prepare the glaze by whisking together the powdered sugar and orange juice until smooth.
Once baked, let the scones cool for a few minutes before drizzling the glaze over them.
Notes
Serve warm on a tiered cake stand or rustic wooden board, garnished with extra cranberries and orange slices.